In 2007 Guiding Catalogue of Industrial Structure Regulation published by National Development and Reform Commission (NDRC), besides the R&D of new drugs, the encougraged projects include the R&D and utilization of key intermediates and new are also listed as encouraged projects, the new adjuvant materials.
A senior insiders said that key intermediates mostly includes the intermediates used for the production of small-market-size cephalosporins. Because technical barriers don't got solved, these intermediates need to be imported from forein countries.
Such as, yearly import amount of 7-ANCA (the intermediate of Ceftizoxime) is over 50 tons; for 7-ACC (the intermediate of Cefaclor) , 7-AVC (the intermediate of Cefixime and Cefdinir), the respective amount is dozens of tons.
Several years ago, the technical barrier don't got solved for GCLE, and GCLE need to be imported from forein countries. In recent two years after solving the technical barrier, China can export GCLE to others countries with a yearly amount of 200-300 tons.